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PyrG leader
In molecular biology, the PyrG leader is a ''cis''-regulatory RNA element found at the 5' of the PyrG mRNA. The PyrG gene encodes a CTP synthase, which is involved in pyrimidine biosynthesis. The PyrG leader regulates expression of PyrG, PyrG can form into two different hairpin structures, a terminator or an anti-terminator. Under low CTP conditions, guanine (G) residues are incorporated at a specific site within the PyrG leader, these allow base-pairing with a uracil (U)-rich region and the formation of an anti-terminator loop, this results in increased expression of PyrG. Under high CTP conditions the guanines are not added, the anti-terminator loop cannot form and instead a terminator loop is formed, preventing further PyrG expression. ==Further reading==
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抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「PyrG leader」の詳細全文を読む
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